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Hippocampal Theta Rhythm

Entrainment of Neocortical Neurons and Gamma Oscillations by the Hippocampal Theta Rhythm

Substantial experimental evidence indicates that gamma oscillations in the neocortex are critical for local computation. However, integration of local computation at multiple locations requires their temporal coordination. Sirota and his colleagues at Rutgers University have demonstrated one such coordinating mechanism, the hippocampal theta oscillation. During both waking and REM sleep, theta oscillations entrained neuronal spiking and gamma bursts in multiple neocortical areas. The theta-gamma entrainment mechanism, therefore, could serve to transfer spatially widespread and locally computed information to the associative networks of the hippocampus.

Sirota A, Montgomery S, Fujisawa S, Isomura Y, Zugaro M, Buzsáki G. Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm. Neuron. 2008 Nov 26;60(4):683-97.